Colorless transparent injection vial containing clear pale greenish yellow liquid

Levofloxacin hydrate 5.1246mg

○ Species having effectiveness
Enterococci, Staphylococcus aureus, Streptococcus pneumoniae, maturation streptococci, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenza, Klebsiella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, Chlamydia pneumoniae, Legionella pneumoniae, mycoplasma pneumoniae
○ Applicable indications
 - Pneumonia to cause community infection
  - Complex urinary tract infections, including acute pyelonephritis
  - Skin and soft tissue infections
  - Acute sinusitis
  - Acute bacterial exacerbation of chronic bronchitis

○ Intravenous infusion as levofloxacin 1-2 times a day up to 14 days.
The dosage shall be determined depending on the type of infection, the symptoms and the sensitivity of estimated organisms. In general, it can be replaced by oral administration of the same dose depending on the state of the first several days after intravenous administration to the patient.
Administer 500mg intravenously over a period of time is 60 minutes or longer.
Duration of treatment will vary depending on the progress of the disease. In general, the administration (injection or tablets) of this drug must continue for at least 48-72 hours after heat is disappeared from the patient or confirming the check result of the bacteria removed.

1. Patient with normal renal function (creatinine clearance greater than 50mL per minute)
Indications / daily dosage (depending on the patient's condition)
Community pneumonia infection / 500mg a dose, 1~2 times a day
Complex urinary tract infection / day, 250mg 1 times
Skin and soft tissue infections including acute pyelonephritis / 500mg once a day
Acute sinusitis / 500mg once a day
Acute bacterial worsening of chronic bronchitis / 500mg once a day
* In case of severe infection, consider increase in dose.

2. Renal insufficiency patients (creatinine clearance is 50 mL or lower per minute)
1) Usual dose of 250mg once a day
Creatinine clearance(mL/min) / initial capacity / holding dose
20 ~ 50 / 250mg / 125mg every 24 hours
10 ~ 19 / 250mg / 125mg every 48 hours
Blood, peritoneal dialysis patient / 250mg / 125mg every 48 hours

2) Usual dose of 500mg once a day
Creatinine clearance(mL/min) / initial capacity / holding dose
20 ~ 50 / 500mg / 250mg every 24 hours
10 ~ 19 / 500mg / 125mg every 24 hours
Blood, peritoneal dialysis patient / 500mg / 125mg every 24 hours

3) Usual dose of 500mg twice a day
Creatinine clearance(mL/min) / initial capacity / holding dose
20 ~ 50 / 500mg / 250mg every 12 hours
10 ~ 19 / 500mg / 125mg every 12 hours
Blood, peritoneal dialysis patient / 500mg / 125mg every 12 hours

* After hemodialysis or continuous ambulatory peritoneal dialysis, additional therapy is not required.

3. Liver disorder patient
Since this drug is not metabolized in liver mostly, it is not necessary to adjust the dose baesd on the liver function.

Colorless transparent injection vial containing clear pale greenish yellow liquid

○ Species having effectiveness

Enterococci, Staphylococcus aureus, Streptococcus pneumoniae, maturation streptococci, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenza, Klebsiella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, Chlamydia pneumoniae, Legionella pneumoniae, mycoplasma pneumoniae

○ Applicable indications

 - Pneumonia to cause community infection

  - Complex urinary tract infections, including acute pyelonephritis

  - Skin and soft tissue infections

  - Acute sinusitis

  - Acute bacterial exacerbation of chronic bronchitis

 

○ Intravenous infusion as levofloxacin 1-2 times a day up to 14 days.

The dosage shall be determined depending on the type of infection, the symptoms and the sensitivity of estimated organisms. In general, it can be replaced by oral administration of the same dose depending on the state of the first several days after intravenous administration to the patient.

Administer 500mg intravenously over a period of time is 60 minutes or longer.

Duration of treatment will vary depending on the progress of the disease. In general, the administration (injection or tablets) of this drug must continue for at least 48-72 hours after heat is disappeared from the patient or confirming the check result of the bacteria removed.

 

1. Patient with normal renal function (creatinine clearance greater than 50mL per minute)

Indications / daily dosage (depending on the patient's condition)

Community pneumonia infection / 500mg a dose, 1~2 times a day

Complex urinary tract infection / day, 250mg 1 times

Skin and soft tissue infections including acute pyelonephritis / 500mg once a day

Acute sinusitis / 500mg once a day

Acute bacterial worsening of chronic bronchitis / 500mg once a day

* In case of severe infection, consider increase in dose.

 

2. Renal insufficiency patients (creatinine clearance is 50 mL or lower per minute)

1) Usual dose of 250mg once a day

Creatinine clearance(mL/min) / initial capacity / holding dose

20 ~ 50 / 250mg / 125mg every 24 hours

10 ~ 19 / 250mg / 125mg every 48 hours

Blood, peritoneal dialysis patient / 250mg / 125mg every 48 hours

 

2) Usual dose of 500mg once a day

Creatinine clearance(mL/min) / initial capacity / holding dose

20 ~ 50 / 500mg / 250mg every 24 hours

10 ~ 19 / 500mg / 125mg every 24 hours

Blood, peritoneal dialysis patient / 500mg / 125mg every 24 hours

 

3) Usual dose of 500mg twice a day

Creatinine clearance(mL/min) / initial capacity / holding dose

20 ~ 50 / 500mg / 250mg every 12 hours

10 ~ 19 / 500mg / 125mg every 12 hours

Blood, peritoneal dialysis patient / 500mg / 125mg every 12 hours

 

* After hemodialysis or continuous ambulatory peritoneal dialysis, additional therapy is not required.

 

3. Liver disorder patient

Since this drug is not metabolized in liver mostly, it is not necessary to adjust the dose baesd on the liver function.